Lionel Cheruzel

Dr. Lionel Cheruzel

Associate Professor
Inorganic and Bioinorganic Chemistry

DH 281
(408) 924-5283
Research Group Page


Postdoctoral Fellow 2006-2009, California Institute of Technology (with Harry B. Gray)
Ph.D. 2004, University of Louisville, Kentucky (with Robert M. Buchanan)
French Engineer Diploma 2000, Montpellier, France.

Courses Taught

Inorganic Chemistry
Bioinorganic Chemistry
General Chemistry I
General Chemistry II

Research Interests

Bioinorganic Chemistry, Inorganic Chemistry, Biochemistry, Development of hybrid enzymes as biocatalysts for hydroxylation of organic substrates using light and water. Molecular imprinted polymers.

Selected Publications

  • Tran, N.-H.; Nguyen, D.; Dwaraknath, S.; Mahadevan, S.; Chavez, G.; Nguyen, A.; Dao, T.; Mullen, S.; Nguyen, T.-A.; Cheruzel, L. E., An Efficient Light-driven P450 BM3 Biocatalyst. Submitted 2013.
  • Dwaraknath, S.; Tran, N. H.; Dao, T.; Colbert, A.; Nguyen, A.; Cheruzel, L., A facile and versatile methodology for selective labeling of cysteine residue with d6 metal complexes. In preparation 2013.
  • Rohan, J. G.; Citron, Y. R.; Durrell, A. C.; Cheruzel, L. E.; Gray, H. B.; Grubbs, R. H.; Humayun, M.; Engisch, K. L.; Pikov, V.; Chow, R. H., Light-triggered modulation of cellular electrical activity by ruthenium diimine nanoswitches. ACS Chem Neurosci, 2013, 4 (4), 585-93. 
  • N.H. Tran, N. Huynh, G. Chavez, A. Nguyen, S. Dwaraknath, T.A Nguyen, M. Nguyen, L.E. Cheruzel* A series of hybrid P450 BM3 enzymes with different catalytic activity in the light-initiated hydroxylation of lauric acid. J. Inorg. Biochem. 2012, 115, 50-57.

  • Tran, N.H.; Huynh, N.; Bui, T.; Nguyen, Y.; Huynh, Y.; Cooper, Cheruzel, L.E. "Light-initiated hydroxylation of lauric acid using hybrid P450 BM3 enzymes" Chem. Commun.2011, 47 11936-11938.
  • Cheruzel, L.E.; Cui, J.L.; Mashuta, M.S.; Grapperhaus, C.A.; Buchanan, R.M. "N-(2-formyl-1-methylimidazol-4-yl)-2,2-dimethylpropan-amide: a versatile reagent for preparing imidazole-amine ligands with variable second-coordination spheres" Tetrahedron Letters2011, 52 4771-4774.