Professor
Biochemistry and Chemical Biology

Office: DH 607
Phone: (408) 924-4962
marc.dalarcao@sjsu.edu

d'Alarcao Group Page

Education

Postdoctoral Fellow 1984-1986, Harvard University (with E.J. Corey)
Ph.D. 1983, University of Illinois, Urbana-Champaign (with Nelson J. Leonard)
B.S. 1978, Bridgewater State College

Courses Taught

Biochemistry
Medicinal Chemistry
Seminar

Research Interests

• Study of inositol glycan-mediated signal transduction;
• Synthetic carbohydrate chemistry;
• Development of new drug delivery strategies;
• Biochemical engineering of cell-surface carbohydrates;
• Development of electrochemically-degradable polymers

Selected Publications

• "Some Natural Flavonoids are Competitive Inhibitors of Caspase-1, -3, and -7 Despite their Cellular Toxicity" J. Brandon White, Jeremy Beckford, Sina Yadegarynia, Nhi Ngo, Tetiana Lialiutska, and Marc d'Alarcao Food Chemistry2012, 131, 1453-59.
• “Modulation of Cellular Adhesion by Glycoengineering” Laila Dafik, Marc d’Alarcao, and Krishna Kumar J. Med. Chem.2010, 53, 4277-4284.
• “The Biological Activity of Structurally Defined Inositol Glycans” Meenakshi Goel, Viatcheslav N. Azev, and Marc d’Alarcao Future Med. Chem.2009, 1, 95-118.
• “Fluorination of Mammalian Cell Surfaces via the Sialic Acid Biosynthetic Pathway” Laila Dafik, Marc d’Alarcao, and Krishna Kumar Bioorg. Med. Chem. Lett.2008, 18, 5945-5947.
• “Synthesis of Differentially Protected myo- and chiro-Inositols from D-Xylose; Stereoselectivity in Intramolecular SmI₂-Promoted Pinacol Reactions” Giovanni Luchetti, Kejia Ding, Alexander Kornienko, and Marc d’Alarcao Synthesis2008, 3148-54.
• “Enantio- and Diastereodivergent Synthetic Route to Multifarious Cyclitols from D-Xylose via Ring-Closing Metathesis” Giovanni Luchetti, Kejia Ding, Marc d’Alarcao, and Alexander Kornienko Synthesis2008, 3142-47.