Brooke Lustig

Brooke Lustig

Adjunct Professor
Biomedical, Chemical, and Materials Engineering
Computational Biochemistry

DH 417
(408) 924-4968


B.A. Molecular Biology & Biochemistry, University of Colorado at Boulder, 1976
Ph.D. Chemistry, University of California at Santa Cruz, 1987

Research Interests

Computation and theoretical methods to characterize entropy and related effects in proteins and RNA, design of potential anti-HIV agents.

Selected Publications

  • Nepal, R., Spencer, J., Bhogal, G., Nedunuri, A., Poelman, T., Kamath, T., Chung, E., Kantardjieff, K., Gottlieb, A, and Lustig, B. "Logistic regression models to predict solvent accessible residues using sequence and homology-based qualitative and quantitative descriptors applied to a domain-complete X-ray structure learning set" (2015JApplCrystallog. 48, 1976-1984.

  • Rose, D., Nepal, R., Gholizadeh, S., Mishra, R., Lau, R., and Lustig, B. "Novel application of query-based qualitative predictors for characterization of solvent accessible residues in conjunction with protein sequence homology" (2011)  Proceedings of the 22nd International Workshop on Database and Expert Systems Applications, 70-74.
  • Liao, H., Yeh, W., Chiang, D., Jernigan, R. L. and Lustig, B. “Protein sequence entropy is closely related to packing density and hydrophobicity” (2005) Prot. Engr. 18, 59-64.
  • Wander, D. S., Yang, F., McNeil, M and Lustig, B. “Scoring DNA sequence alignment using energetics of hybridization” (2003) Proceedings of Annual Meeting of American Institute of Chemical Engineers T2/555b(1-8).  
  • Hsieh, M., Collins, E. D., Blomquist, T. and Lustig, B. "Flexibility of BIV TAR-Tat: Models of peptides binding" (2002) J. Biomol. Struct. Dyn. 20, 243-251.
  • Lustig, B. and Jeang K.-T. "Biological applications of hammerhead ribozymes as anti-viral molecules" (2001) Current Medicinal Chemistry 8, 1181-1187.
  • Lustig, B., Bahar, I. and Jernigan, R. L. "RNA bulge entropies correlate with peptide binding strengths for HIV-1 and BIV TAR RNA because of improved conformational access" (1998) Nucleic Acids Res. 26, 5212-5217.