Marc d'Alarcao

Marc d'Alarcao

Associate Dean of Research

Office: DH 282 
Phone: (408) 924-4962

d'Alarcao Group Page


Postdoctoral Fellow 1984-1986, Harvard University (with E.J. Corey)
Ph.D. 1983, University of Illinois, Urbana-Champaign (with Nelson J. Leonard)
B.S. 1978, Bridgewater State College

Courses Taught

Medicinal Chemistry
General Chemistry

Research Interests

Chemical Biology, Organic Chemistry, Biochemistry. Synthesis and biological evaluation of carbohydrates. Medicinal chemistry. Study of inositol glycan-mediated signal transduction. Development of new drug delivery strategies; Biochemical engineering of cell-surface carbohydrates. Development of electrochemically-degradable polymers.

Selected Publications

  • "Sialidases as Regulators of Bioengineered Cellular Surfaces" Cristina Y. Zamora, Matthew J. Ryan, Marc d'Alarcao, and Krishna Kumar Glycobiology 2015, 25 (7), 784-91. doi: 10.1093/glycob/cwv019 [html]
  • "Total synthesis of trifluorobutyryl-modified, globally protected sialyl Lewis X by a convergent [2+2] approach" Gizem Akçay, John Y. Ramphal, Marc d'Alarcao, and Krishna Kumar Tetrahedron Lett. 2015, 56, 109-14. doi:10.1016/j.tetlet.2014.11.029. [html]
  • “Insulin-mimicking Bioactivities of Acylated Inositol Glycans in Several Mouse Models of Diabetes with or without Obesity” Susumu Suzuki, Chitose Suzuki, Yoshinori Hinokio, Yasushi Ishigaki, Hideki Katagiri, Makoto Kanzaki, Viatcheslav N. Azev, Nilanjana Chakraborty, and Marc d’Alarcao PLoS ONE  2014, 9 (6), e100466. [html] [pdf]                
  • “Fluorogenic Sialic Acid Glycosides for Quantification of Sialidase Activity Upon Unnnatural Substrates”Cristina Y. Zamora, Marc d’Alarcao, and Krishna Kumar,Bioorg. Med. Chem. Lett.  2013, 23, 3406-3410. [html]
  • "Some Natural Flavonoids are Competitive Inhibitors of Caspase-1, -3, and -7 Despite their Cellular Toxicity" J. Brandon White, Jeremy Beckford, Sina Yadegarynia, Nhi Ngo, Tetiana Lialiutska, and Marc d'Alarcao Food Chemistry  2012, 131, 1453-59. [pdf]