Welcome to the Cheruzel Research lab
SJSU Tower Hall
Summer 2014 Lab Potluck
Celebration of the end of semester, traditional lab potluck and group picture
Dr Cheruzel at CanBIC with Dr Gray and Dr Dawson
Dr Harry Gray, Dr Lionel Cheruzel, and Dr John Dawson at CanBIC-5
Communication in the Journal of the American Chemical Society
Cheruzel Wins Herbert Tabor Young Investigator Award
Lionel Cheruzel, an assistant professor at San Jose State University in California
since 2009, won a Herbert Tabor Award for his work on light-driven hybrid P450 BM3
Cheruzel Wins Early Career Investigator Award
Chemistry professor Lionel Cheruzel has been named one of two Early Career Investigator
Award winners by the San Jose State University Research Foundation. Cheruzel (pictured
with research student Ngoc-Han Tran) was recognized for excellence in the areas of
research, scholarship, or creative activity.
Spring 2015 Chem 131B
A group of students who graduated in Spring 2015 after taking Chem 131B with Dr. Cheruzel.
Welcome to all of the new students joining the lab this summer! We look forward to
working with you all.
Alejandro Cortez graduated from SJSU with a BS in Biochemistry.
Sarah Mullen successfully defended her thesis
The specific and selective oxidation of an unactivated C-H bond remains one of the
most challenging reactions in organic chemistry. Cytochrome P450 is a unique superfamily
of heme-thiolate enzymes that catalyze the insertion of an oxygen atom, derived from
molecular dioxygen, into a C-H bond of a variety of organic substrates, often with
high degrees of regio- and stereoselectivity. Recent interests in these proteins arise
from the desire to harness their synthetic potential for biotechnological applications.
Our laboratory focuses on developing hybrid P450 biocatalysts capable of the selective
oxidation of organic substrate C-H bonds upon light activation. The hybrid enzymes
consist of a photosensitizer covalently attached to P450 heme domains.