Publications

Publications and Patents


(45) “Sialidases as Regulators of Bioengineered Cellular Surfaces” Cristina Y. Zamora, Matthew J. Ryan, Marc d’Alarcao, and Krishna Kumar Glycobiology 2015, 25, 784-791. doi: 10.1093/glycob/cwv019 [html]


(44) “Total synthesis of trifluorobutyryl-modified, globally protected sialyl Lewis X by a convergent [2+2] approach” Gizem Akçay, John Y. Ramphal, Marc d’Alarcao, and Krishna Kumar Tetrahedron Lett. 2015, 56, 109-14. doi:10.1016/j.tetlet.2014.11.029. [html]


(43) “Insulin-mimicking Bioactivities of Acylated Inositol Glycans in Several Mouse Models of Diabetes with or without Obesity” Susumu Suzuki, Chitose Suzuki, Yoshinori Hinokio, Yasushi Ishigaki, Hideki Katagiri, Makoto Kanzaki, Viatcheslav N. Azev, Nilanjana Chakraborty, and Marc d’Alarcao PLoS ONE  2014, 9 (6), e100466. [html] [pdf]


(42) “Fluorogenic Sialic Acid Glycosides for Quantification of Sialidase Activity Upon Unnnatural Substrates” Cristina Y. Zamora, Marc d’Alarcao, and Krishna Kumar Bioorg. Med. Chem. Lett. 2013,23, 3406-3410. [html]


(41) “Electrochemically Degradable Polymers” P. Calias and M. d’Alarcao, U.S. Patent Application; Filing date: June 18, 2012; Publication Date by WIPO: Dec. 27, 2013. [html]


(40) “Some Natural Flavonoids are Competitive Inhibitors of Caspase-1, -3, and -7 Despite their Cellular Toxicity” J. Brandon White, Jeremy Beckford, Sina Yadegarynia, Nhi Ngo, Tetiana Lialiutska, and Marc d’Alarcao Food Chemistry  2012, 131, 1453-59. [html]


(39) “Modulation of Cellular Adhesion by Glycoengineering” Laila Dafik, Marc d’Alarcao, and Krishna Kumar J. Med. Chem.  2010, 53, 4277-4284. [html] [pdf]


 (38) “The Biological Activity of Structurally Defined Inositol Glycans” Meenakshi Goel, Viatcheslav N. Azev, and Marc d’Alarcao Future Med. Chem. 2009, 1, 95-118. [pdf]


 (37) “Fluorination of Mammalian Cell Surfaces via the Sialic Acid Biosynthetic Pathway”Laila Dafik, Marc d’Alarcao, and Krishna Kumar Bioorg. Med. Chem. Lett. 2008, 18, 5945-5947. [pdf]


(36) “Synthesis of Differentially Protected myo- and chiro-Inositols from D-Xylose; Stereoselectivity in Intramolecular SmI2-Promoted Pinacol Reactions” Giovanni Luchetti, Kejia Ding, Alexander Kornienko, and Marc d’Alarcao Synthesis  2008, 3148-54. [pdf]


(35) “Enantio- and Diastereodivergent Synthetic Route to Multifarious Cyclitols from D-Xylose via Ring-Closing Metathesis” Giovanni Luchetti, Kejia Ding, Marc d’Alarcao, and Alexander Kornienko Synthesis 2008, 3142-47. [pdf]


(34) “Use and Synthesis of Inositol Glycans for Cancer Therapy” Susumu Suzuki, Viatcheslav Azev, and Marc d’Alarcao, U.S. Provisional Patent Application; Filing date: Dec. 21, 2006; Publication Date by WIPO: July 3, 2008. [html] [pdf]


(33) “Introduction of Fluorinated Carbohydrates on Mammalian Cell Surfaces and their use in Tumor Visualization Tissue Engineering, and Cancer Therapy” Marc d’Alarcao, Laila Dafik, and Krishna Kumar, U.S. Provisional Patent Application; Filing date: Feb. 2, 2006; Publication Date by WIPO: Sept. 20, 2007. [html]


(32) “Synthesis of Galactosaminyl D-chiro-Inositols” Georgia Marnera and Marc d’Alarcao* Carbohydr. Res.2006, 341, 1105-1116. [pdf]


(31) “Electrochemically Degradable Polymers” P. Calias and M. d’Alarcao, U.S. Patent Application; Filing date: October 14, 2004; Publication Date by WIPO: April 27, 2006. [html] [pdf]


(30) “An Anionic Inositol Phoshate Glycan Pseudotetrasaccharide Exhibits High Insulin-Mimetic Activity in Rat Adipocytes” Nilanjana Chakraborty and Marc d’Alarcao Bioorg. Med. Chem. 2005, 13, 6732-41. [pdf]


(29) “A Fluorescent Inositol Phosphate Glycan Stimulates Lipogenesis in Rat Adipocytes by Extracellular Activation Alone” David I. Turner, Nilanjana Chakraborty, and Marc d’Alarcao, Bioorg. Med. Chem. Lett.  200515, 2023-25. [pdf]


(28) “Synthesis of 1,2-Diamino-1,2-dideoxy-myo-inositol-Derived Ligands for the Investigation of Metal Complex Reactivity” V. N. Azev and M. d'Alarcao J. Org. Chem. 2004, 69, 4839. [pdf]


(27) “Synthesis of Inositol Glycan Cyclic Phosphates” C. H. Jaworek, S. Iacobucci, P. Calias, and M. d'Alarcao Carbohydr. Res. 2001, 331, 375-391. [pdf]


(26) “Synthesis of Cyclitols via Ring-Closing Metathesis” A. Kornienko and M. d’Alarcao Tetrahedron: Asymmetry  1999, 10, 827-829. [pdf]


(25) “Synthesis of an Inositol-Containing Trisaccharide Related to Insulin Signal Transduction” C. H. Jaworek, P. Calias, S. Iacobucci, and M. d'Alarcao Tetrahedron Lett.  1999, 40, 667. [pdf]


(24) “Practical Synthesis of a Differentially Protected myo-Inositol” A. Kornienko, D. I. Turner, C. H. Jaworek, and M. d’Alarcao Tetrahedron: Asymmetry  1998, 9, 2783. [pdf]


(23) “Synthesis of a Jojoba Bean Disaccharide” A. Kornienko, G. Marnera, and M. d’Alarcao Carbohydr. Res. 1998, 310, 141. [pdf]


(22) “Enantiospecific Synthesis of a Differentially Protected L-chiro-Inositol from D-Xylose” A. Kornienko and M. d’Alarcao Tetrahedron Lett.  1997, 38, 6497. [pdf]


(21) “Synthesis of Inositol-2-phosphate-Quercetin Conjugates”  P. Calias, T. Galanopoulos, M. Maxwell, A. Khayat, D. Graves, H. N. Antoniades, and M. d’Alarcao Carbohydr. Res. 1996, 292, 83. [pdf]


(20) “Formation and Cell-Medium Partitioning of Autoinhibitory Free Fatty Acids and Cyclodextrin’s Effect in the Cultivation of Bordetella pertussis” B. T. Frohlich, M. d’Alarcao, R. S. Feldberg, M. L. Nicholson, G. R. Siber, and R. W. Swartz J. Biotechnol.  1996, 45, 137.


(19) “Methods for Increasing the Bioavailability of Biological Active Agents” H. N. Antoniades, M. d’Alarcao, and Helion Povoa U.S. Patent Application # 08/455,681; Filing date: May 31, 1995. [html]


(18) “Deprotection of p-Methoxyphenyl Pyranosides by Anodic Oxidation” S. Iacobucci, N. Filippova, and M. d’Alarcao Carbohydr. Res. 1995, 277, 321.


(17) “A Simple Synthesis of D-Myo-Inositol 4-Phosphate and D-Myo-Inositol 6-Phosphate” S. Iacobucci and M. d’Alarcao Synth. Commun. 1994, 24, 809.


(16) “Synthesis and Characterization of an Insulin-Mimetic Disaccharide” R. Plourde, M. d'Alarcao, and A. R. Saltiel J. Org. Chem.  1992, 57, 2606.


(15) “Synthesis of a Potentially Insulin-Mimetic Disaccharide” R. Plourde and M. d'Alarcao Tetrahedron Lett.  1990, 31, 2693.


(14) “Synthesis of 3'-Cyano-2',3'-dideoxyadenosine and 2',3'-Dideoxy-3'-formyladenosine” D. Yu and M. d'Alarcao J. Org. Chem.  1989, 54, 3240.


(13) “Involvement of Icosanoids in Endothelium-Derived Relaxing Factor” P. Uotila, C. Cunard, R. Vargas, M. d'Alarcao, S. Matsuda, E.J. Corey, and P.W. Ramwell Adv. Prostaglandin, Thromboxane, Leukotriene Res.  1987, 17, 1103.


(12) “The Vasodilatation Induced by Hydroperoxy Metabolites of Arachidonic Acid in the Rat Mesenteric and Pulmonary Circulation” M. d'Alarcao, E.J. Corey, C. Cunard, P. Ramwell, P. Uotila, R. Vargas, and B. Wrobleska  Br. J. Pharmacol. 1987, 91, 627.


(11) “Relaxing Effects of 15-Lipoxygenase Products of Arachidonic Acid on Rat Aorta” P. Uotila, R. Vargas, B.Wrobleska, M. d'Alarcao, S.P. Matsuda, E.J. Corey, C.M. Cunard, and P.W. Ramwell J. Pharmacol. Exp. Therap. 1987, 242, 945.


(10) “The Intermediacy of 8-HPETE in the Conversion of Arachidonic Acid to Pre-clavulone A by Clavularia viridis. The First  Example of the Hydroperoxide Cyclase Mechanism in the Biosynthesis of a Marine Prostanoid” E.J. Corey, M. d'Alarcao, S.P.T. Matsuda, P.T. Lansbury, Jr., and Y.Yamada J. Am. Chem. Soc. 1987, 109, 289.


(9) “12-Methylidine-10(Z),13(Z)-nonadecadienoic Acid, A New Irreversible Inhibitor of Soybean Lipoxygenase” E.J.Corey and Marc d'Alarcao Tetrahedron Lett.  1986, 27, 3589-90.


(8) “A New Irreversible Inhibitor of Soybean Lipoxygenase; Relevance to Mechanism” E.J. Corey, M. d'Alarcao, and S.P.T. Matsuda Tetrahedron Lett.  1986, 27, 3585-88.


(7) “Synthesis of New Lipoxygenase Inhibitors 13-Thia- and 10-Thiaarachidonic Acids” E.J. Corey, M. d'Alarcao, and K.S. Kyler Tetrahedron Lett. 1985, 26, 3919-22.


(6) “Rearrangements of Azabiphenylenes. The Impact of Nitrogen Number and Position” K.J. Gibson, M. d'Alarcao, and N.J. Leonard J. Org. Chem.  1985, 50, 2462-68.


(5) “Synthesis of Imidazo[4,5-h]-1,3-Diazabiphenylene (lin-Benzocyclobutadienopurine), a Ring System Having a Benzocyclobutadieno Spacer Between the Terminal Rings of Purine” M. d'Alarcao, V. Bakthavachalam, and N.J. Leonard J. Org. Chem.  1985, 50, 2456-61.


(4) “Synthesis and Chemistry of 1,3-Diazabiphenylenes” V. Bakthavachalam, M. d'Alarcao, and N.J. Leonard J. Org. Chem. 1984, 49, 289-95.


(3) “Synthesis and Transilience of a 1,3-Diazabiphenylene” M. d'Alarcao and N.J. Leonard J. Am. Chem. Soc. 1983, 105, 5958-60.


(2) “Specifically Deuterated and Tritiated Auxins” L.L.Melhado, C.J. Pearce, M. d'Alarcao, and N.J. Leonard Phytochemistry  1982, 21, 2879-85.


(1) “Characterization of DNA Adenine Methylation Mutants of E. coli  K12” A. Bale, M. d'Alarcao, and M.G. Marinus Mutation Research  1979, 59, 157-65.