Glycoengineering

Publications and Patents


“Sialidases as Regulators of Bioengineered Cellular Surfaces” Cristina Y. Zamora, Matthew J. Ryan, Marc d’Alarcao, and Krishna Kumar Glycobiology 2015, 25, in press. doi: 10.1093/glycob/cwv019 [html]


“Total synthesis of trifluorobutyryl-modified, globally protected sialyl Lewis X by a convergent [2+2] approach” Gizem Akçay, John Y. Ramphal, Marc d’Alarcao, and Krishna Kumar Tetrahedron Lett. 2015, 56, 109-14. doi:10.1016/j.tetlet.2014.11.029. [html]


“Fluorogenic Sialic Acid Glycosides for Quantification of Sialidase Activity Upon Unnnatural Substrates” Cristina Y. Zamora, Marc d’Alarcao, and Krishna Kumar Bioorg. Med. Chem. Lett. 2013, 23, 3406-3410. [html]


“Modulation of Cellular Adhesion by Glycoengineering” Laila Dafik, Marc d’Alarcao, and Krishna Kumar J. Med. Chem.  2010, 53, 4277-4284. [html] [pdf]


“Fluorination of Mammalian Cell Surfaces via the Sialic Acid Biosynthetic Pathway” Laila Dafik, Marc d’Alarcao, and Krishna Kumar Bioorg. Med. Chem. Lett. 2008, 18, 5945-5947. [pdf]


“Introduction of Fluorinated Carbohydrates on Mammalian Cell Surfaces and their use in Tumor Visualization Tissue Engineering, and Cancer Therapy” Marc d’Alarcao, Laila Dafik, and Krishna Kumar, U.S. Provisional Patent Application; Filing date: Feb. 2, 2006; Publication Date by WIPO: Sept. 20, 2007. [html]