Inositols and Inositol Glycans

Publications and Patents


“Insulin-mimicking Bioactivities of Acylated Inositol Glycans in Several Mouse Models of Diabetes with or without Obesity” Susumu Suzuki, Chitose Suzuki, Yoshinori Hinokio, Yasushi Ishigaki, Hideki Katagiri, Makoto Kanzaki, Viatcheslav N. Azev, Nilanjana Chakraborty, and Marc d’Alarcao PLoS ONE  2014, 9 (6), e100466. [html] [pdf]


“The Biological Activity of Structurally Defined Inositol Glycans” Meenakshi Goel, Viatcheslav N. Azev, and Marc d’Alarcao Future Med. Chem. 2009, 1, 95-118. [pdf]


“Synthesis of Differentially Protected myo- and chiro-Inositols from D-Xylose; Stereoselectivity in Intramolecular SmI2-Promoted Pinacol Reactions” Giovanni Luchetti, Kejia Ding, Alexander Kornienko, and Marc d’Alarcao Synthesis  2008, 3148-54. [pdf]


“Enantio- and Diastereodivergent Synthetic Route to Multifarious Cyclitols from D-Xylose via Ring-Closing Metathesis” Giovanni Luchetti, Kejia Ding, Marc d’Alarcao, and Alexander Kornienko Synthesis 2008, 3142-47. [pdf]


“Use and Synthesis of Inositol Glycans for Cancer Therapy” Susumu Suzuki, Viatcheslav Azev, and Marc d’Alarcao, U.S. Provisional Patent Application; Filing date: Dec. 21, 2006; Publication Date by WIPO: July 3, 2008. [html] [pdf]


“Synthesis of Galactosaminyl D-chiro-Inositols” Georgia Marnera and Marc d’Alarcao*Carbohydr. Res.2006, 341, 1105-1116. [pdf]


“An Anionic Inositol Phoshate Glycan Pseudotetrasaccharide Exhibits High Insulin-Mimetic Activity in Rat Adipocytes” Nilanjana Chakraborty and Marc d’Alarcao Bioorg. Med. Chem. 2005, 13, 6732-41. [pdf]


“A Fluorescent Inositol Phosphate Glycan Stimulates Lipogenesis in Rat Adipocytes by Extracellular Activation Alone” David I. Turner, Nilanjana Chakraborty, and Marc d’Alarcao,Bioorg. Med. Chem. Lett.  200515, 2023-25. [pdf]


“Synthesis of 1,2-Diamino-1,2-dideoxy-myo-inositol-Derived Ligands for the Investigation of Metal Complex Reactivity” V. N. Azev and M. d'Alarcao J. Org. Chem. 2004, 69, 4839. [pdf]


“Synthesis of Inositol Glycan Cyclic Phosphates” C. H. Jaworek, S. Iacobucci, P. Calias, and M. d'Alarcao Carbohydr. Res. 2001, 331, 375-391. [pdf]


“Synthesis of Cyclitols via Ring-Closing Metathesis” A. Kornienko and M. d’AlarcaoTetrahedron: Asymmetry  1999, 10, 827-829. [pdf]


“Synthesis of an Inositol-Containing Trisaccharide Related to Insulin Signal Transduction” C. H. Jaworek, P. Calias, S. Iacobucci, and M. d'Alarcao Tetrahedron Lett. 1999, 40, 667. [pdf]


“Practical Synthesis of a Differentially Protected myo-Inositol” A. Kornienko, D. I. Turner, C. H. Jaworek, and M. d’Alarcao Tetrahedron: Asymmetry  1998, 9, 2783. [pdf]


“Synthesis of a Jojoba Bean Disaccharide” A. Kornienko, G. Marnera, and M. d’AlarcaoCarbohydr. Res. 1998, 310, 141. [pdf]


“Enantiospecific Synthesis of a Differentially Protected L-chiro-Inositol from D-Xylose” A. Kornienko and M. d’Alarcao Tetrahedron Lett.  1997, 38, 6497. [pdf]


“Synthesis of Inositol-2-phosphate-Quercetin Conjugates”  P. Calias, T. Galanopoulos, M. Maxwell, A. Khayat, D. Graves, H. N. Antoniades, and M. d’Alarcao Carbohydr. Res. 1996, 292, 83. [pdf]


“Methods for Increasing the Bioavailability of Biological Active Agents” H. N. Antoniades, M. d’Alarcao, and Helion Povoa U.S. Patent Application # 08/455,681; Filing date: May 31, 1995. [html]


“A Simple Synthesis of D-Myo-Inositol 4-Phosphate and D-Myo-Inositol 6-Phosphate” S. Iacobucci and M. d’Alarcao Synth. Commun. 1994, 24, 809.


“Synthesis and Characterization of an Insulin-Mimetic Disaccharide” R. Plourde, M. d'Alarcao, and A. R. Saltiel J. Org. Chem.  1992, 57, 2606.


“Synthesis of a Potentially Insulin-Mimetic Disaccharide” R. Plourde and M. d'AlarcaoTetrahedron Lett.  1990, 31, 2693.