| 1779 | March 15 | William Lamb born. |
| 1781 | Caroline's brother John William Ponsonby (later Lord Duncannon) born. | |
| 1783 | July 6 | Caroline's brother Frederick Cavendish Ponsonby born. |
| 1785 | August 16 | Caroline Rosalie St. Jules (later “Caro George”) born. |
| August 29 | Harriet Elizabeth Cavendish (“Harryo”) born. | |
| November 13 | Caroline Ponsonby (later Lady Caroline Lamb) born. | |
| 1787 | Caroline's brother William (“Willy”) Francis Spencer Ponsonby (her favorite) born. | |
| 1788 | January 22 | George Gordon, 6th Lord Byron born. |
| 1790 | William Spencer Cavendish, Marquis of Hartington (“Hart,” later the 6th Duke of Devonshire) born. | |
| 1791 | November | Caroline leaves for Europe with her mother and aunt Georgiana, the Duchess of Devonshire, who has been banished by the Duke (“Canis”) for becoming pregnant by her lover, Earl Grey. |
| 1793 | January | Louis XVI of France guillotined. |
| March 11 | Lord Bessborough dies, making her father the 3rd Earl Bessborough and Caroline officially “Lady Caroline.” | |
| May | Caroline's Aunt Georgiana and Lady Elizabeth Foster are permitted by the Duke of Devonshire to return to England, but her mother, Harriet, is too ill to travel. | |
| October | Marie Antoinette guillotined. | |
| 1793-1794 | Caroline suffers a life-threatening illness in Italy, and her mother, Harriet, falls in love with Granville Leveson Gower. | |
| 1794 | August | Caroline's mother is well enough to travel home to England. |
| 1799 | William Lamb takes his degree at Cambridge and goes to Glasgow to study. | |
| 1802 | March | The ill-fated Treaty of Amiens signed, negotiated by Pitt the Younger. |
| August | Caroline and William Lamb meet and are infatuated. | |
| 1803 | May 18 | Britain declares war on France. |
| 1805 | June 3 | Caroline and William Lamb are married. |
| 1806 | February 1 | Caroline delivers a girl, who dies shortly after. |
| William elected Member of Parliament for Leominster. | ||
| March 30 | Caroline's Aunt Georgiana, Duchess of Devonshire, dies. | |
| November | William opens Parliament and Caroline sneaks in dressed as a man to watch proudly. | |
| 1807 | August 29 | Caroline's son Augustus born. |
| 1809 | October 19 | Lady Elizabeth Foster marries 5th Duke of Devonshire (Canis). |
| May 17 | George Lamb marries Caroline Rosalie Adelaide St. Jules. | |
| December 24 | Granville marries “Harryo” (Lady Harriet Elizabeth Cavendish). |
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| 1810 | March/April | Caroline begins an affair with Sir Godfrey Vassal Webster, son of Lady Holland by her first marriage. |
| 1811 | February 5 | Regency bill becomes law, and “Prinny” (the Prince of Wales) assumes the royal duties because George II is incapacitated by porphyria. |
| July | Caroline's affair with Webster ends. | |
| July 29 | Frederick Cavendish, 5th Duke of Devonshire, dies, making “Hart” the 6th Duke. | |
| 1812 | March 10 | Childe Harold's Pilgrimage officially published. |
| March 25 | Byron attends a waltzing party at Lady Caroline Lamb's. Their affair begins. | |
| August 12 | Caroline runs away and Byron manages to bring her home. | |
| September | Caroline is taken to Ireland by her family. | |
| November | Byron delivers the blow: Caroline is no longer his lover. | |
| 1813 | January | Caroline forges Byron's handwriting to obtain a painting from John Murray. |
| July 5 | Caroline cuts herself in a chaotic scene at Lady Heathcote's ball. | |
| August 10 | Austria declares war on France. | |
| 1814 | Caroline's brother Willy marries Lady Barbara Ashley Cooper. | |
| March 18 | Caroline's grandmother Lady Spencer dies. | |
| March 28 | Byron moves into the Albany. | |
| Spring | Caroline meets Isaac Nathan, who arranges music in honor of her brother Willy's engagement. | |
| May 4 | Napoleon exiled; arrives on Elba. | |
| July 1 | Caroline attends a masked ball at Burlington House held by Watier's Club to Honor the Duke of Wellington's victory over Napoleon. | |
| 1815 | January 2 | Byron is married at Seaham to Annabella Milbanke |
| March 20 | Napoleon returns to power in France. | |
| March 28 | The Byrons settle at 13 Piccadilly Terrace (house of the Duchess of Devonshire). | |
| April | Nathan and Byron's Hebrew Melodies volume 1 published. | |
| June 18 | Napoleon defeated at Waterloo. | |
| August 11 | Viscount Melbourne created Lord Melbourne in the peerage of the UK. | |
| August 12 | Granville Leveson-Gower created Viscount Granville. | |
| William and Caroline visit Brussels and Paris. | ||
| October 16 | Napoleon exiled to Saint Helena. | |
| 1816 | April 18 | Nathan and Byron's Hebrew Melodies volume 2 published. |
| April 21 | Byron signs deed of separation from his wife. | |
| April 24 | Byron leaves London for the Continent. | |
| May 9 | Lady Caroline's first novel, Glenarvon, published by Henry Colburn. | |
| July 7 | Richard Brinsley Sheridan dies; afterward, William is elected Member of Parliament for Northampton. | |
| November 18 | Canto III of Byron's Childe Harold published in London. | |
| 1817 | July 14 | Madame de Staël dies. |
| 1818 | March | Susan Spencer Churchill born to Harriet Caroline Spencer; the illegitimate child becomes Lady Bessborough's ward. |
| April 6 | Lady Melbourne dies. | |
| Spring | Emily Cowper (William's sister) fights to get Lady Caroline admitted to Almack's Club. | |
| 1819 | February/March | Lady Caroline canvasses for William's brother George Lamb's election, in which he defeats John Cam Hobhouse. |
| July 15 | Byron's Don Juan Cantos 1 and 2 published. | |
| October | Lady Caroline's A New Canto (satire of Don Juan) published. | |
| 1820 | January 29 | George III dies. |
| February 16 | George III buried. | |
| April 27 | George IV opens Parliament. | |
| Summer | Lady Caroline appears at Almack's dressed as Don Juan with attendant devils. | |
| August | Queen Caroline's trial for adultery with her courier, Bartolommeo Bergami, begins and will last through November. She is acquitted. | |
| 1821 | July 19 | George IV's coronation at Westminster Abbey. |
| August 7 | Queen Caroline (George IV's estranged wife) dies. | |
| August 8 | Byron's Don Juan Cantos 3-5 published. | |
| Fall | Caroline's Gordon: A Tale (another satire of Don Juan) published. | |
| November 5 | The infant son of Lady Caroline's brother William and Lady Barbara dies in Parma. | |
| November 11 | Lady Bessborough dies in Florence. | |
| 1822 | January 28 | Annabella's mother dies (Lady Noel) and Lord and Lady Byron assume the additional name of Noel. |
| April 19 | Byron's daughter Allegra dies. | |
| Fall | Caroline's Graham Hamilton published by Henry Colburn. | |
| 1823 | March | Caroline's Ada Reis published by John Murray. |
| 1824 | March 30 | Lady Elizabeth Foster, Duchess of Devonshire, dies. |
| April 19 | Lord Byron dies in Greece, the victim of doctors who dehydrate him through bleeding. | |
| May 17 | Byron's memoirs are burned at John Murray's offices in Albermarle Street, and it is disclosed that Murray let Caroline read them. | |
| June 29 | The Florida arrives in England with Byron's remains. | |
| July 12 | Byron's funeral cortege leaves London and passes through Welwyn, Hertfordshire, where Caroline encounters it. | |
| July 16 | Byron's funeral. | |
| October 23 | Medwin's Conversations of Lord Byron published and Caroline reads his vitriolic “Remember Thee” for the first time. | |
| 1825 | Summer | William finally succumbs to family pressure to separate from Caroline, who signs separation agreement, meets Wilmington Fleming, and departs for Paris. |
| October | Lady Caroline back in London; Doctor Goddard makes diagnosis of insanity. | |
| 1826 | January | Lady Caroline returns to Brocket. |
| 1827 | April | William appointed Chief Secretary to the Lord Lieutenant for Ireland, takes Augustus with him. |
| September | Caroline becomes severely ill with “dropsy.” | |
| 1828 | January 15 | William notified Caroline likely to die. |
| January 25 | Lady Caroline dies, William having arrived just in time to speak with her. | |
| July 22 | William's father finally dies at age 83, and William becomes Lord Melbourne. | |
| 1836 | Caroline and William's son, Augustus, dies. | |
| 1837 | George IV dies. | |
| Lord Cowper dies, leaving William's sister Emily free to marry Lord Palmerston, future Prime Minister. | ||
| 1838 | Victoria crowned Queen. | |
| 1848 | William Lamb dies. | |
| 1853 | Frederick Lamb dies. | |
| 1858 | Hart, the 6th Duke of Devonshire, dies. | |
| 1860 | Lady Byron dies. | |
| 1862 | Caroline St. Jules Lamb (“Caro George”) dies. | |
| Harryo dies. | ||
| 1864 | Isaac Nathan dies in Sydney, Australia. | |
| 1869 | Emily Palmerston (formerly Lamb, then Cowper) dies. |