Teratogens
Some lab experiments may use chemicals that are considered teratogens. Below is a list of teratogens that are a part of the College of Science's chemical inventory. If you are pregnant, think you are pregnant or trying to get pregnant, please contact your professor or lab instructor to find out if any of these chemicals may be used in your lab during the semester.
In 1986, California passed Proposition 65, the Safe Drinking Water and Toxic Enforcement Act.This Proposition shifts the burden of proof in the regulatory process from government to industry. Use of chemicals known to cause cancer or reproductive toxicity is no longer considered "innocent" until proven "guilty" of harming public health by governmental agencies. Identified hazards are placed on a list and automatically become subject to the Act's warning requirements (12 months after listing) and discharge prohibition (20 months after listing). Exemptions from these requirements are allowed only if the business responsible for an exposure or discharge can demonstrate that the amount of chemical in question poses "no significant risk."
- Teratogens in the Lab
- Proposition 65 List [PDF] from OEHHA.ORG
| Regulatory Name | Synonyms (Sigma/Aldrich) | C.A.S. Number |
|---|---|---|
| Acetohydroxomic acid | 546-88-3 | |
| Alprazolam | 28981-97-7 | |
| Actinomycin D (98%) | 50-76-0 | |
| Amikacin sulfate | Amikacin: Sulfate ratio 1:2 | 39831-55-5 |
| Aminoglutethimide | 125-84-8 | |
| Aminoglycosides | None listed | |
| Aminopterin | 4-Aminofolic acid | 54-62-6 |
| Amiodarone Hydrochloride | 19774-82-4 | |
| Anabolic Steroids | (see 1997 Sigma Cat. p1940) | Various |
| Arsenic Trioxide | Arsenic (III) oxide | 1327-53-3 |
| Arsenic Acid, Potassium salt | Potassium Arsenate | 7784-41-0 |
| Arsenic Acid, Sodium salt | Sodium Arsenate | 10048-95-0 |
| Arsenious Acid, Sodium salt | Sodium m-Arsenite | 7784-46-5 |
| Aspirin has warnings about usage during pregnancy) | Acetylsalicylic acid | 50-78-2 |
| Atenolol | 29122-68-7 | |
| Azathioprine | 446-86-6 | |
| Barbital | 5,5-Diethylbarbituric Acid | 57-44-3 |
| Barbital, Sodium salt | Sodium Barbital | 144-02-5 |
| Barbituric Acid | 2,4,6-Trihydroxypyrimidine | 67-52-7 |
| Benomyl | 17804-35-2 | |
| Benzopyrene, 3,4- | Benz[a]pyrene | 50-32-8 |
| Benzopyrene, 4,5- | Benz[e]pyrene | 192-97-2 |
| Benzphetamine hydrochloride | N-Benzyl-N-alpha-dimethylpenethylamine | 5411-22-3 |
| Busulfan | 1,4-Butanediol dimethylsulfonate | 55-98-1 |
| Butabarbital, Sodium | (Sigma has the free acid only) | 143-81-7 |
| Cadmium compounds | (see 1997 Sigma Cat. p1940) | Various |
| Carbon disulfide | 75-15-0 | |
| Carbon monoxide | 630-08-0 | |
| Carboplatin | cis-Diammine(1,1-cyclobutanedicarboxylato) Platinum | 41575-94-4 |
| Chenodiol | Chenodeoxycholic Acid | 474-25-9 |
| Chlorambucil | 305-03-3 | |
| Chlorcyclizine hydrochloride | 1620-21-9 | |
| Chlordiazepoxide | (Hydrochloride only-Sigma) | 58-25-3 |
| Chlordiazepoxide hydrochloride | 438-41-5 | |
| 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea | Lomustine | 13010-47-4 |
| Cladribine | 2-Chloro-2'-deoxyadeno-sine | 4291-63-8 |
| Clomiphene citrate | 50-41-9 | |
| Cocaine free base | Ecgonine methyl ester benzoate | 50-36-2 |
| Cocaine hydrochloride | 53-21-4 | |
| Colchicine | ||
| Cycloheximide | 66-81-9 | |
| Cyclophosphamide (anhyd. & hydrated | (Sigma of the monohydrate) | 6055-19-2 |
| Cytarabine | Cytosine-beta-D-arabinofuranoside | 147-94-4 |
| Danazol | 17230-88-5 | |
| Daunorubicin Hydrochloride | Daunomycin Hydrochloride | 23541-50-6 |
| Demechlocycline Hydro-chloride (internal use) | 7-Chloro-6-demethyltetracycline hydrochloride | 64-73-3 |
| Diazepam | 439-14-5 | |
| 1,2-Dibromo-3-chloropropane | (DBCP) | 96-12-8 |
| Dicumarol | 3,3'-Methylenebis-(4-hydroxycoumarin) | 66-76-2 |
| Diethylstilbesterol | DES | 56-53-1 |
| Dihydroergotamine Mesylate | (Methanesulfonate) | 6190-39-2 |
| o-Dinitrobenzene | 1,2-Dinitrobenzene | 528-29-0 |
| m-Dinitrobenzene | 1,3-Dinitrobenzene | 99-65-0 |
| p-Dinitrobenzene | 1,4-Dinitrobenzene | 100-25-4 |
| m-Dinitrobenzoic acid | 3,4 Dinitrobenzoic Acid | 528-45-0 |
| Dinoseb | 2-sec-Butyl-4,6-dinitrophenol | 88-85-7 |
| 5,5-Diphenylhydantoin | Phenytoin free acid | 57-41-0 |
| Doxycycline anhydrous, calcium salt & monohydrate (internal use) | (Sigma offers the hydrochloride) | 564-25-094088-85-417086-28-1 |
| beta-Estradiol | 50-28-2 | |
| Epichlorhydrin | 1-Chloro-2,3-epoxypropane | 106-89-8 |
| Epinepherine | ||
| Ergotamine Tartrate | 379-79-3 | |
| Estrogens, conjugated | 12126-59-9 | |
| Ethanol in alcoholic beverages | 64-17-5 | |
| Ethionamide | 2-Ethyl-4-pyridinecarbothioamide | 536-33-4 |
| Ethoxyethanol, 2- | 110-80-5 | |
| Ethoxyethyl acetate, 2- | 111-15-9 | |
| Ethyleneglycol monomethyl ether acetate | 110-49-6 | |
| Ethylene oxide | 75-21-8 | |
| Ethylene thiourea | 2-Imidazolidinethione | 96-45-7 |
| Etoposide | 33419-42-0 | |
| Fluorouracil | 2,4-Dihydroxy-5-fluoropyrimidine | 51-21-8 |
| Flurazepam hydrochloride | Flurazepam dihydrochloride | 1172-18-5 |
| Flutamide | 13311-84-7 | |
| Fluoxymesterone | 9-alpha-Fluoro-11-beta-hydroxy-17-alpha-methyltestosterone | 76-43-7 |
| Formamide | ||
| Halothane | 2-Bromo-2-chloro-1,1,1-trifluoroethane | 151-67-7 |
| Hexachlorobenzene | 118-74-1 | |
| Hexamethyl phosphoramide | 680-31-9 | |
| Hydroxyurea | 127-07-1 | |
| Iodine-131 | 10043-66-0 | |
| Isotretinoin | 13-cis-Retinoic Acid | 4759-48-2 |
| Lead inorganic compounds (dust) | (7439-92-1) | |
| Lithium carbonate | 554-13-2 | |
| Lithium citrate | 919-16-4 | |
| Lorazepam | (+-)-Lorazepam | 846-49-1 |
| Mechlorethamine hydrochloride | 2-Chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride or Nitrogen Mustard hydrochloride | 55-86-7 |
| Medroxyprogesterone acetate | 6-alpha-Methyl-17-alpha-hydroxyprogesterone acetate | 71-58-9 |
| Megestrol Acetate | 595-33-5 | |
| Melphalan | 4-[bis(2-chloroethyl)amino]-L-phenylalanine | 148-82-3 |
| Meprobamate | 2-Methyl-2-propylpropane-1,3-diolcarbamate | 57-53-4 |
| Mercaptopurine | 6-Mercaptopurine hydrate | 6122-76-1 |
| Mercuric acetate | 1600-27-7 | |
| Mercury inorganic compounds (dust) | (7439-97-6) | |
| Methacycline Hydrochloride | 3963-95-9 | |
| Methimazole | 60-56-0 | |
| Methotrexate | (+)-Amethopterin | 59-05-2 |
| Methotrexate Sodium | 15475-56-6 | |
| Methoxyethanol, 2- | Ethylene glycol monomethyl ether | 109-86-4 |
| Methyl mercury | 593-74-8 | |
| Methyl formamide | 123-39-7 | |
| Mesterone | Methyl testosterone (17-alpha-) | 58-18-4 |
| Midizolam (Hydrochloride) | Sigma offers the Maleate 1:1 | 59467-94-6 |
| Minocycline hydro-chloride (inter'l use) | 13614-98-7 | |
| Mitoxanthrone Hydrochloride | 65271-80-9 | |
| Oxazepam | 604-75-1 | |
| Oxymetholone | Anasterone | 434-07-1 |
| Oxytetracycline (internal use) | (Sigma offers the dihydrate) | 79-57-2(6153-64-6) |
| Oxytetracycline Hydro- chloride (internal use) | 2058-46-0 | |
| Neomycin sulfate (internal use) | 1405-10-3 | |
| Netilmicin sulfate | 1-N-Ethylsisomicin | 56391-57-2 |
| Nickel Carbonyl | 13463-39-3 | |
| Nicotine | (-)-Nicotine free base (natural) | 54-11-5 |
| Nitrofurantoin | N-(5-Nitro-2-furylidene)-1-aminohydantoin | 67-20-9 |
| Norethisterone | 19-Norethindrone | 68-22-4 |
| Norethisterone acetate | 19-Norethindrone acetate | 51-98-9 |
| Norgestrel | D-(-)-Norgestrel | 6533-00-2 |
| Paclitaxel | from Taxus brevifolia from Taxus yannanensis | 33069-62-4 |
| Penicillamine | D-(-)-Penicillamine free base | 52-67-5 |
| Pentobarbital, Sodium salt | Sodium pentobarbital | 57-33-0 |
| Phenobarbital | 50-06-6 | |
| Phenyl mercuric acetate | 62-38-4 | |
| Phenylmercuric nitrate | 8003-05-2 | |
| Polychlorinated biphenyls (PCB's) | (Sigma offers an EPA Standard) | 1336-36-3 |
| Propylthiorouracil | 6-n-Propyl-2-thiouracil | 51-52-5 |
| Secobarbital, sodium | 309-43-3 | |
| Streptomycin sulfate | 3810-74-0 | |
| Retinol acetate & palmatate (Vitamin A) have warnings about daily internal usage | all-trans-Retinol Acetate and all-trans-Retinol Palmitate | 127-47-979-81-2 |
| all-trans-Retinoic Acid | Vitamin A Acid | 302-79-4 |
| Tamofixen Citrate | 54965-24-1 | |
| Temazepam | 846-50-4 | |
| Testosterone Enanthate | 315-37-7 | |
| Testosterone (17-beta-) Cipionate | 58-20-8 | |
| Tetracyclines (Internal use) | Tetracycline free base Tetracycline-Hydrochloride Tetracycline phosphate complex | 60-54-864-75-51336-20-5 |
| Thalidomide | 50-35-1> | |
| Thioguanine, 6- | 2-Amino-6-mercaptopurine | 154-42-7 |
| Tobramycin sulfate | 79645-27-5> | |
| Toluene | 108-88-3 | |
| Triazolam | 28911-01-5 | |
| Trypan blue | 72-57-1 | |
| Urethane | Ethyl carbamate | 51-79-6 |
| Valproate (Valproic Acid) | 2-Propylpentanoic acid | 99-66-1 |
| Vinblastine sulfate | 143-67-9 | |
| Vincristine sulfate | 2068-78-2 | |
| Warfarin | 3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin | 81-81-2 |