Teratogens

Some lab experiments may use chemicals that are considered teratogens. Below is a list of teratogens that are a part of the College of Science's chemical inventory. If you are pregnant, think you are pregnant or trying to get pregnant, please contact your professor or lab instructor to find out if any of these chemicals may be used in your lab during the semester.

In 1986, California passed Proposition 65, the Safe Drinking Water and Toxic Enforcement Act.This Proposition shifts the burden of proof in the regulatory process from government to industry. Use of chemicals known to cause cancer or reproductive toxicity is no longer considered "innocent" until proven "guilty" of harming public health by governmental agencies. Identified hazards are placed on a list and automatically become subject to the Act's warning requirements (12 months after listing) and discharge prohibition (20 months after listing). Exemptions from these requirements are allowed only if the business responsible for an exposure or discharge can demonstrate that the amount of chemical in question poses "no significant risk."

Regulatory Name Synonyms (Sigma/Aldrich) C.A.S. Number
Acetohydroxomic acid 546-88-3
Alprazolam 28981-97-7
Actinomycin D (98%) 50-76-0
Amikacin sulfate Amikacin: Sulfate ratio 1:2 39831-55-5
Aminoglutethimide 125-84-8
Aminoglycosides None listed
Aminopterin 4-Aminofolic acid 54-62-6
Amiodarone Hydrochloride 19774-82-4
Anabolic Steroids (see 1997 Sigma Cat. p1940) Various
Arsenic Trioxide Arsenic (III) oxide 1327-53-3
Arsenic Acid, Potassium salt Potassium Arsenate 7784-41-0
Arsenic Acid, Sodium salt Sodium Arsenate 10048-95-0
Arsenious Acid, Sodium salt Sodium m-Arsenite 7784-46-5
Aspirin has warnings about usage during pregnancy) Acetylsalicylic acid 50-78-2
Atenolol 29122-68-7
Azathioprine 446-86-6
Barbital 5,5-Diethylbarbituric Acid 57-44-3
Barbital, Sodium salt Sodium Barbital 144-02-5
Barbituric Acid 2,4,6-Trihydroxypyrimidine 67-52-7
Benomyl 17804-35-2
Benzopyrene, 3,4- Benz[a]pyrene 50-32-8
Benzopyrene, 4,5- Benz[e]pyrene 192-97-2
Benzphetamine hydrochloride N-Benzyl-N-alpha-dimethylpenethylamine 5411-22-3
Busulfan 1,4-Butanediol dimethylsulfonate 55-98-1
Butabarbital, Sodium (Sigma has the free acid only) 143-81-7
Cadmium compounds (see 1997 Sigma Cat. p1940) Various
Carbon disulfide 75-15-0
Carbon monoxide 630-08-0
Carboplatin cis-Diammine(1,1-cyclobutanedicarboxylato) Platinum 41575-94-4
Chenodiol Chenodeoxycholic Acid 474-25-9
Chlorambucil 305-03-3
Chlorcyclizine hydrochloride 1620-21-9
Chlordiazepoxide (Hydrochloride only-Sigma) 58-25-3
Chlordiazepoxide hydrochloride 438-41-5
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea Lomustine 13010-47-4
Cladribine 2-Chloro-2'-deoxyadeno-sine 4291-63-8
Clomiphene citrate 50-41-9
Cocaine free base Ecgonine methyl ester benzoate 50-36-2
Cocaine hydrochloride 53-21-4
Colchicine
Cycloheximide 66-81-9
Cyclophosphamide (anhyd. & hydrated (Sigma of the monohydrate) 6055-19-2
Cytarabine Cytosine-beta-D-arabinofuranoside 147-94-4
Danazol 17230-88-5
Daunorubicin Hydrochloride Daunomycin Hydrochloride 23541-50-6
Demechlocycline Hydro-chloride (internal use) 7-Chloro-6-demethyltetracycline hydrochloride 64-73-3
Diazepam 439-14-5
1,2-Dibromo-3-chloropropane (DBCP) 96-12-8
Dicumarol 3,3'-Methylenebis-(4-hydroxycoumarin) 66-76-2
Diethylstilbesterol DES 56-53-1
Dihydroergotamine Mesylate (Methanesulfonate) 6190-39-2
o-Dinitrobenzene 1,2-Dinitrobenzene 528-29-0
m-Dinitrobenzene 1,3-Dinitrobenzene 99-65-0
p-Dinitrobenzene 1,4-Dinitrobenzene 100-25-4
m-Dinitrobenzoic acid 3,4 Dinitrobenzoic Acid 528-45-0
Dinoseb 2-sec-Butyl-4,6-dinitrophenol 88-85-7
5,5-Diphenylhydantoin Phenytoin free acid 57-41-0
Doxycycline anhydrous, calcium salt & monohydrate (internal use) (Sigma offers the hydrochloride) 564-25-094088-85-417086-28-1
beta-Estradiol 50-28-2
Epichlorhydrin 1-Chloro-2,3-epoxypropane 106-89-8
Epinepherine
Ergotamine Tartrate 379-79-3
Estrogens, conjugated 12126-59-9
Ethanol in alcoholic beverages 64-17-5
Ethionamide 2-Ethyl-4-pyridinecarbothioamide 536-33-4
Ethoxyethanol, 2- 110-80-5
Ethoxyethyl acetate, 2- 111-15-9
Ethyleneglycol monomethyl ether acetate 110-49-6
Ethylene oxide 75-21-8
Ethylene thiourea 2-Imidazolidinethione 96-45-7
Etoposide 33419-42-0
Fluorouracil 2,4-Dihydroxy-5-fluoropyrimidine 51-21-8
Flurazepam hydrochloride Flurazepam dihydrochloride 1172-18-5
Flutamide 13311-84-7
Fluoxymesterone 9-alpha-Fluoro-11-beta-hydroxy-17-alpha-methyltestosterone 76-43-7
Formamide
Halothane 2-Bromo-2-chloro-1,1,1-trifluoroethane 151-67-7
Hexachlorobenzene 118-74-1
Hexamethyl phosphoramide 680-31-9
Hydroxyurea 127-07-1
Iodine-131 10043-66-0
Isotretinoin 13-cis-Retinoic Acid 4759-48-2
Lead inorganic compounds (dust) (7439-92-1)
Lithium carbonate 554-13-2
Lithium citrate 919-16-4
Lorazepam (+-)-Lorazepam 846-49-1
Mechlorethamine hydrochloride 2-Chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride or Nitrogen Mustard hydrochloride 55-86-7
Medroxyprogesterone acetate 6-alpha-Methyl-17-alpha-hydroxyprogesterone acetate 71-58-9
Megestrol Acetate 595-33-5
Melphalan 4-[bis(2-chloroethyl)amino]-L-phenylalanine 148-82-3
Meprobamate 2-Methyl-2-propylpropane-1,3-diolcarbamate 57-53-4
Mercaptopurine 6-Mercaptopurine hydrate 6122-76-1
Mercuric acetate 1600-27-7
Mercury inorganic compounds (dust) (7439-97-6)
Methacycline Hydrochloride 3963-95-9
Methimazole 60-56-0
Methotrexate (+)-Amethopterin 59-05-2
Methotrexate Sodium 15475-56-6
Methoxyethanol, 2- Ethylene glycol monomethyl ether 109-86-4
Methyl mercury 593-74-8
Methyl formamide 123-39-7
Mesterone Methyl testosterone (17-alpha-) 58-18-4
Midizolam (Hydrochloride) Sigma offers the Maleate 1:1 59467-94-6
Minocycline hydro-chloride (inter'l use) 13614-98-7
Mitoxanthrone Hydrochloride 65271-80-9
Oxazepam 604-75-1
Oxymetholone Anasterone 434-07-1
Oxytetracycline (internal use) (Sigma offers the dihydrate) 79-57-2(6153-64-6)
Oxytetracycline Hydro- chloride (internal use) 2058-46-0
Neomycin sulfate (internal use) 1405-10-3
Netilmicin sulfate 1-N-Ethylsisomicin 56391-57-2
Nickel Carbonyl 13463-39-3
Nicotine (-)-Nicotine free base (natural) 54-11-5
Nitrofurantoin N-(5-Nitro-2-furylidene)-1-aminohydantoin 67-20-9
Norethisterone 19-Norethindrone 68-22-4
Norethisterone acetate 19-Norethindrone acetate 51-98-9
Norgestrel D-(-)-Norgestrel 6533-00-2
Paclitaxel from Taxus brevifolia from Taxus yannanensis 33069-62-4
Penicillamine D-(-)-Penicillamine free base 52-67-5
Pentobarbital, Sodium salt Sodium pentobarbital 57-33-0
Phenobarbital 50-06-6
Phenyl mercuric acetate 62-38-4
Phenylmercuric nitrate 8003-05-2
Polychlorinated biphenyls (PCB's) (Sigma offers an EPA Standard) 1336-36-3
Propylthiorouracil 6-n-Propyl-2-thiouracil 51-52-5
Secobarbital, sodium 309-43-3
Streptomycin sulfate 3810-74-0
Retinol acetate & palmatate (Vitamin A) have warnings about daily internal usage all-trans-Retinol Acetate and all-trans-Retinol Palmitate 127-47-979-81-2
all-trans-Retinoic Acid Vitamin A Acid 302-79-4
Tamofixen Citrate 54965-24-1
Temazepam 846-50-4
Testosterone Enanthate 315-37-7
Testosterone (17-beta-) Cipionate 58-20-8
Tetracyclines (Internal use) Tetracycline free base Tetracycline-Hydrochloride Tetracycline phosphate complex 60-54-864-75-51336-20-5
Thalidomide 50-35-1>
Thioguanine, 6- 2-Amino-6-mercaptopurine 154-42-7
Tobramycin sulfate 79645-27-5>
Toluene 108-88-3
Triazolam 28911-01-5
Trypan blue 72-57-1
Urethane Ethyl carbamate 51-79-6
Valproate (Valproic Acid) 2-Propylpentanoic acid 99-66-1
Vinblastine sulfate 143-67-9
Vincristine sulfate 2068-78-2
Warfarin 3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin 81-81-2